RESUMO
Sera obtained from rabbits and humans after unilateral nephrectomy (uni sera) compared with sera obtained preoperatively (control sera) significantly stimulate 3H-thymidine incorporation into the DNA of cultured renal tissue from the respective species. In contrast, rabbit liver cells in culture are not stimulated by the uni sera compared with control sera obtained from rabbits. Mouse epidermal growth factor (EGF) added to tissue cultures significantly stimulates both kidney and liver cells of rabbits and kidney cells of humans. Antiserum against EGF overcomes, at least to some extent, the enhancing effect of EGF under all circumstances, but does not influence the stimulatory ability of uni serum obtained from rabbit and human kidney cells from the respective species. In addition, the activity of EGF was not different in the presence of uni and control sera. This study corroborates the presence of renotropic activity in the sera of rabbits and humans after removal of functioning renal mass and shows that this activity is not derived from EGF, nor does it work by potentiating some aspect of the EGF system.
Assuntos
Fator de Crescimento Epidérmico/fisiologia , Substâncias de Crescimento/fisiologia , Peptídeos e Proteínas de Sinalização Intercelular , Animais , Células Cultivadas , DNA/biossíntese , Fator de Crescimento Epidérmico/sangue , Fator de Crescimento Epidérmico/farmacologia , Humanos , Rim/citologia , Rim/metabolismo , Fígado/citologia , Fígado/metabolismo , Nefrectomia , CoelhosAssuntos
Dexametasona/efeitos adversos , Diabetes Mellitus Experimental/metabolismo , Hexobarbital/efeitos adversos , Estresse Fisiológico/metabolismo , Animais , Temperatura Baixa , Dexametasona/metabolismo , Dexametasona/uso terapêutico , Diabetes Mellitus Experimental/tratamento farmacológico , Diabetes Mellitus Experimental/fisiopatologia , Feminino , Hexobarbital/metabolismo , Hexobarbital/uso terapêutico , Temperatura Alta , Masculino , Ratos , Ratos EndogâmicosRESUMO
The effects of the calcium antagonists verapamil and nifedipine on blood glucose levels, glucose tolerance, insulin secretion during glucose tolerance and hypoglycaemic effect of tolbutamide were studied in normal nondiabetic rabbits. Daily dosage of 40 mg/kg verapamil and 5 mg/kg nifedipine given orally up to 7 days did not affect blood glucose level, glucose tolerance, insulin secretion during glucose tolerance and hypoglycaemic activity of tolbutamide 250 mg/kg p.o.
Assuntos
Glicemia/metabolismo , Bloqueadores dos Canais de Cálcio/farmacologia , Animais , Teste de Tolerância a Glucose , Insulina/metabolismo , Secreção de Insulina , Masculino , Nifedipino/farmacologia , Coelhos , Tolbutamida/farmacologia , Verapamil/farmacologiaRESUMO
In the last two and one-half years a suburban community hospital, through its parent corporation, invested $8 million in four new companies in an effort to diversify its revenue base. The important lessons learned during the process--including the need for a dedicated diversification team, commitment of funds equal to 150 percent of those required, and allocation of sufficient funds for marketing--can help healthcare organizations contemplating a similar revenue diversification effort.
Assuntos
Administração Financeira de Hospitais , Administração Financeira , Administração Hospitalar/economia , Reestruturação Hospitalar/economia , Convênios Hospital-Médico/economia , California , Hospitais com 300 a 499 Leitos , Investimentos em SaúdeRESUMO
Are physicians being left out as hospitals rush to form outpatient surgery centers, diagnostic imaging centers, home health agencies, and other new financial ventures? Joint ventures and revenue diversification offer an often unexplored means for medical group practice to profit from the many financial opportunities created by the changing reimbursement system. Out-lined here are the considerations involved in the formation of an alternative health delivery system to help medical group practices gain a greater share of the healthcare dollar.
